Enantioselective copper-catalyzed 1,3-dipolar cycloadditions.
نویسندگان
چکیده
منابع مشابه
Copper(II)-catalyzed exo and enantioselective cycloadditions of azomethine imines.
A strategy for exo and enantioselective 1,3-dipolar cycloaddition of azomethine imines to 2-acryloyl-3-pyrazolidinone is described. The corresponding cycloadducts are isolated with high diastereoselectivities (up to >96:4 exo/endo) and enantioselectivities (up to 98% ee).
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Synthetic methods relying on gold complexes as catalysts have recently been the focus of intense development.1 Despite numerous advances, relatively few enantioselective gold-catalyzed transformations have been described. The earliest example of an enantioselective gold(I)-catalyzed transformation, the Hayashi-Ito aldol reaction, was proposed to rely on activation of the nucleophile as a chiral...
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[reaction: see text] A general strategy for highly enantioselective 1,3-dipolar cycloaddition of diazoesters to beta-substituted, alpha-substituted, and alpha,beta-disubstituted alpha,beta-unsaturated pyrazolidinone imides is described. Cycloadditions utilizing less reactive alpha,beta-disubstituted dipolarophiles require elevated reaction temperatures, but still provide the corresponding pyraz...
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Monodentate phosphoramidite ligands are used to accelerate the copper(i)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(i) and Cu(ii) salts both function as the copper source in aqueous solution to provide excellent yields.
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ورودعنوان ژورنال:
- Chemical reviews
دوره 108 8 شماره
صفحات -
تاریخ انتشار 2008